Ho Chi Minh City (Saigon) is the most popular place to go from Phnom Penh. It takes 6h 30m to get there. Siem Reap is the second most popular place to go from Phnom Penh. It takes 6h to get there.
You can find directions from your current location here: https://www.google.com/maps/dir//HWXG+8Q Phnom Penh, Cambodia
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