La Serena to Santiago Trip Overview
Distance 398 km (248.8 miles) | |
Price range US$ 12-US$ 38 | |
Ride Duration Range 5h 40m-8h | |
Earliest Departure 04:15 | |
Latest Departure 22:00 | |
Most Popular Operator |
Find up-to-date information on departure times, schedules, and prices so you can easily compare and book your tickets.
Taking a bus from La Serena to Santiago
Fastest bus: 5h 40m
Cheapest bus: US$ 12

About the ride from La Serena to Santiago
La Serena to Santiago Route Information
The distance between La Serena and Santiago is 249 miles, or approximately 398 kilometers.
There are 2 ways to get from La Serena to Santiago, including bus,flight.
The earliest departure leaves at 04:15 and has a duration of 6 hours 45 minutes.
The fastest way to travel is by bus, which takes approximately 5 hours 40 minutes.
La Serena to Santiago by bus
- Starting Price: US$ 12
- 581 departures a day, or 4067 departures a week
There are 19 travel classes for this journey, including: Sleeping, Premium Sleeping, Express, Semi-Sleeper, Premium Class, VIP 32 Seats, Private Sleeper, Low Cost Sleeper, Low Cost Semi Sleeper, Single Sleeper Premium, Single Sleeper, Sleeper, Suite Premium, Economy Semi Sleeper, Semi Sleeper Premium, Economy Sleeper, Standard, Premium and Single Suite Sleeper.
Each bus ticket offers an individual seat with basic passenger necessities. Conditions and amenities vary by provider. For more detailed information and availability see all bus options.
La Serena to Santiago by flight
The only travel class available is Economy.
Each flight ticket offers an individual seat with basic passenger necessities. Conditions and amenities vary by provider. For more detailed information and availability see all flight options.
Companies Operating from La Serena to Santiago
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